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KMID : 1143420230160110305
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Public Health Weekly Report
2023 Volume.16 No. 11 p.305 ~ p.320
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Serotype Distribution of Streptococcus pneumoniae from Respiratory Specimen of Children with Pneumonia in the Republic of Korea, 2018?2022
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Lee Jin
Yu Sa-Rah
Jang Jun-Hyeong
Kim Jun-Young
Yoo Jae-Il
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Abstract
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Streptococcus pneumoniae is the major pathogen causing pneumonia, bacteraemia and meningitis, and one of the leading causes of death in children. In the Republic of Korea (ROK), the national pneumococcal vaccination program for children was inoculated with protein conjugated vaccines 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent PCV (PCV13). It is very important to analyze the S. pneumoniae serotypes isolated in the ROK to confirm the vaccine efficacy by PCV introduction. In this study, 116 S. pneumoniae were isolated from respiratory specimen of children with pneumonia through an acute respiratory infections network (ARI-NET) from 2018 to 2022. The isolated strains were divided into PCV13 and non-PCV13, and serotypes were analyzed. A total of 15 serotypes and other non-typeable S. pneumoniae (NTSp) were confirmed. The distributions of PCV13, non-PCV13 and NTSp serotypes were 9.5%, 87.9% and 2.6%, respectively. The main serotypes consisted of 6C, 23A, 15B, 15C/23B, 10A, 34/35B, 19A, 19F, and 15A, in that order, accounting for 92.2% of all isolates. There were 15 serotypes distributed at ages <5 years, with 91% non-PCV13 serotypes, and the major serotypes were identified in the order 6C, 15B, 23A, 15C, and 23B. Non-PCV13 serotypes 6C and 23A accounted for the highest distribution in the age ages >5 years. This study showed the ratio of serotypes not included in the vaccine was relatively higher than that of the serotypes included in the PCV13. In order to manage pneumococcal infection and confirm the vaccine efficacy, it is necessary to continuously operate an ARI-NET and analysis of changes in S. pneumoniae serotype.
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KEYWORD
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Streptococcus pneumoniae, Serotype, 13-valent pneumococcal conjugate vaccine, Children, Pneumonia
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